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It has been a rough month for markets. Waves of bad news from Europe and weak data from of China have helped keep stocks low.

What can we look forward to?

More of the same, and worse according to these 13 experts.?

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Is Google Acquiring HP?s WebOS Enyo Team?

There are reports doing the rounds suggesting that Google might be poaching HP?s team working on Enyo, which is a webOS HTML5 based framework that debuted on the TouchPad. The news puts a huge question mark on the future of the ?Open webOS? project that HP had promised.

HP is working on a project to make the webOS software an open source platform and the Enyo team is supposed to be a team at the centre of the development of the project. As per HP?s strategy, they are supposed to offer version 1 by late 2012.

Also when it comes to the team?s move to Google it is unclear right now as to which team these guys would be a part of. With Android?s design Chief Matias Duarte having been previously associated with Palm during its Pre launch, there is a chance that the Enyo team might be a part of the Android development platform. The webOS platform though not highly successful, is considered to be an innovative platform and there is surely a thing or two for Android to learn and adopt from it.

Besides the team can also be part of the Chrome group, where web apps (read HTML5 based apps) are central to its development, which is exactly what the Enyo team?s core functioning at HP was. It?s also believed that though it?s not the entire team that?s leaving HP, Matt McNulty who led the Enyo team along with its core developers responsible for the entire coding for the platform will be leaving.

HP has not commented on these rumors but has reaffirmed their commitment to the Open webOS project and reassured that the project is on schedule. There has been no official statement from Google on this front as well.

Is Google Acquiring HP?s WebOS Enyo Team?

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Obama's re-election campaign releases video challenging Mitt Romney's record at Bain Capital (Star Tribune)

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Google goes cancer: Researchers use search engine algorithm to find cancer biomarkers

Google goes cancer: Researchers use search engine algorithm to find cancer biomarkers

Friday, May 18, 2012

The strategy used by Google to decide which pages are relevant for a search query can also be used to determine which proteins in a patient's cancer are relevant for the disease progression. Researchers from Dresden University of Technology, Germany, have used a modified version of Google's PageRank algorithm to rank about 20,000 proteins by their genetic relevance to the progression of pancreatic cancer. In their study, published in PLoS Computational Biology, they found seven proteins that can help to assess how aggressive a patient's tumor is and guide the clinician to decide if that patient should receive chemotherapy or not.

The researcher's own version of the Google algorithm has been used in this study to find new cancer biomarkers, which are molecules produced by cancer cells. Biomarkers can help to detect cancer earlier in body fluids or directly in the cancer tissue obtained in an operation or biopsy. Finding these biomarkers is often difficult and time consuming. Another problem is that markers found in different studies for the same types of cancer almost never overlap.

This problem has been circumvented using the Google strategy, which takes into account the content of a web page and also how these pages are connected via hyperlinks. With this strategy as the model, the authors made use of the fact that proteins in a cell are connected through a network of physical and regulatory interactions; the 'protein Facebook' so to speak.

"Once we added the network information in our analysis, our biomarkers became more reproducible," said Christof Winter, the paper's first author. Using this network information and the Google Algorithm, a significant overlap was found with an earlier study from the University of North Carolina. There, a connection was made with a protein which can assess aggressiveness in pancreatic cancer.

Although the new biomarkers seem to mark an improvement over currently used diagnostic tools, they are far from perfect and still need to be validated in a larger follow-up study before they can be used in clinical practice. It remains an open problem to turn these insights into novel drugs which slow down cancer progression. A first step in this direction is the group's cooperation with the Dresden-based biotech company RESprotect, who are running a clinical trial on a pancreas cancer drug.

TU Dresden is a leading German university, whose Center for Regenerative Therapies was awarded excellence status in the national excellence initiative. The work was a cooperation between the bioinformatics group of Prof. Dr. Michael Schroeder and the medical groups of Dr. Christian Pilarsky and Prof. Robert Gr?tzmann.

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Winter C, Kristiansen G, Kersting S, Roy J, Aust D, et al. (2012) Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes. PLoS Comput Biol 8(5): e1002511. doi:10.1371/journal.pcbi.1002511

Public Library of Science: http://www.plos.org

Thanks to Public Library of Science for this article.

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